Do you feel like you just
      can't wrap your arms
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      protocol?

Biomolecular Nutrigenomics


This field of study incorporates the tenets of nutrigenomics but takes this a step further by analyzing the molecular signaling pathways that are affected by specific, single site base changes and then utilizes a combination of nutrients, foods, and natural RNAs to bypass mutations and restore proper pathway function.


Dr. Amy Yasko PHD,
Microbiology/Immunology/Infectious Disease

 

 

Genetic Testing &

Single Nucleotide Polymorphisms

 

The human genome is a string of over 3 billion chemical letters that spell out every inherited trait. Although the letters of all our genomes are virtually identical and have little variation, more and more frequently, nature gets a letter wrong, similar to a typo. Scientists call these genetic misspellings SNPs (snips), or single nucleotide polymorphisms, which occur as variations at a single site in DNA. In fact, an SNP is the most frequent variation in the human genome with about 5-10 million of them, although not all of these disparities contribute to disease. Scientists are using them to diagnose medical disorders, craft superior medications, and tailor a treatment regimen that can essentially circumvent such mutations much like Dr. Amy Yasko’s biomolecular nutrigenomics protocol with regard to ADHD/ADD, autism, neurobehavioral disorders, chronic fatigue syndrome, fibromyalgia, Gulf War Syndrome, and a multitude of neurological, gastro-intestinal, and other multisystem autoimmune diseases and disorders.

I think that most would agree that it is important to address all of the contributing factors that lead to disease.  One definitive way to evaluate the genetic contribution of multifactorial disease is to take advantage of new methods and technology that allow for personalized genetic screening. Genetic testing offers a way to evaluate and address the hereditary component contributing to multifactorial disease and is available to identify a number of underlying inherited susceptibilities based on SNP variations found in the DNA. This process systematically compares genomes of those individuals with an imbalance in a nutritional pathway to the corresponding DNA of those from standard populations. A number of leading universities, biotechnology and pharmaceutical companies as well as prominent scientists (such as Dr. Bruce Ames, one of the world’s most renowned molecular biologists) are intensively scrutinizing this field of science as well as conducting ongoing research in order to present a comprehensive map of the genetic differences that help explain why we vary in health, appearance and even behavior.

 

Simply put, nutrigenomics is the study of how the food we eat, and the nutrients therein, impact our health. This is largely based upon our own unique genetic make up, which makes it the ultimate personalized diet plan. Most are aware that overeating highly refined, processed foods contributes to obesity but what about seemingly inconsequential issues such as adding folate, one of the B vitamins, to most of our processed foods in order to prevent spina bifida? Does everyone process folate well and, if not, does this have an impact on our health? It just might be that it does.   This is one reason that individual genetic make up becomes vital. If you have the MTHFR C677T SNP defect as my husband and son do, or even a partial defect, you cannot use plain folate very well, hence, you won’t have many of the nutrients you need for important bodily functions. Not only that, if you can’t use the folate that is loaded in all of the foods you eat, this excess folate may actually become harmful to you, building up as toxic byproducts. In fact, extensive research has already been done in this area that recognizes heart disease, Alzheimers, and even certain cancers as a risk factor due to this genetic defect.

 

There are numerous ways in which the food we eat or the supplements we take may prove harmful which makes it so important to study these food-gene interactions further. Fortunately, the days of a one size fits all diet, food pyramid, and nutritional program are finally behind us while science continues to advance in directions that lead to more promise with highly sophisticated, yet more affordable, genetic tests as well as exceptionally targeted treatment regimens. Biomolecular nutrigenomics studies this interaction by evaluating the individual’s body chemistry in order to determine how these deficiencies and deleterious substances wreak havoc within the entire system, thus leading to signs and symptoms of illness and disease. Anyone who has experienced unexplained aches and pains or persistent fatigue and mood changes may have the standard blood testing done with their medical provider and yet, many times, all of the results are “normal”. How can this be? There are many factors that lead to such vague symptoms and in medicine, we only test for the most common causes such as thyroid disorders, anemia, infection, liver and kidney dysfunction or electrolyte disturbances, to name a few. Nevertheless such testing doesn’t begin to account for all of the problems that lead to poor health and loss of wellbeing.

 

Biomolecular nutrigenomics offers a solution for many who have sought answers, only to find that conventional medicine is often limited to treating the symptoms of disease and dysfunction, rather than targeting the root cause. This expanding field of science and medicine provides an opportunity for the millions who suffer from previously unexplained disease processes such as chronic fatigue syndrome, fibromyalgia, irritable bowel syndrome, autism, chronic headaches & migraines, depression, anxiety and panic attacks, insomnia, and memory loss as well as a host of already established disease processes including heart disease, dementia, Parkinson’s disease, autoimmune syndromes, and cancers, to name but a few. Furthermore, it is the most comprehensive approach to date in that it encompasses the genetic foundations, a host of environmental exposures and triggers, and distinct individual factors along with many of the consequences. For the first time in history, we are granted an opportunity to address the source of many disease processes that are considered incurable as well as many of the contributing factors AND the most troublesome symptoms; welcome to the 21st century! As this scientific field expands and more specialists begin utilizing this medicine in their own clinical practice, we may finally realize the dream of personalized medicine. In the meantime, I look forward to sharing this extraordinary path to healing with you!

 

  

 

References

 

Chaney, S. Nutrigenomics—The future of Nutrition. Textbook of biochemistry. 7th Ed., 2011 1094-1095.

Casci T. Genetics: SNPs that come in threes. 2010 Jan;11(1):8. Nat Gen Res.

Chauhan, A., Chauhan, V., & Brown, T. W., Autism: Oxidative stress, inflammation, and immune abnormalities. 2010.

Gray, I.C., Campbell, D.A., Spurr, N.K. Single nucleotide polymorphisms as tools in human genetics. Hum Mol Genet. 2000 Oct;9(16):2403-8.

Kaput, J, & Rodriguez, R.L., Nutritional Genomics: discovering the path to personalized nutrition. 2006.

Nathan, N. On hope and healing: For those who have fallen through the medical cracks. 2010.   

Payseur, B.A., Cutter, A.D. Integrating patterns of polymorphism at SNPs and STRs. Trends Genet. 2006 Aug;22(8):424-9.

Shaw, W. Biological treatments for autism and PDD. 2008.

Soslau, G. Single-strand conformation polymorphism. Textbook of biochemistry, 7th Ed., 2011, 270-274.

Wakeley, J., Nielsen, R., Liu-Cordero, S.N., Ardlie, K. The discovery of single-nucleotide polymorphisms—and inferences about human demographic history. Am J Hum Genet. 2001 Dec;69(6):1332-47.

Yasko, A. Biomolecular nutrigenomic analysis of the methylation cycle. A Synopsis of Genetic Bypass. 2004.

 

Yasko, A. Autism: Pathway to Recovery. 2009.

 

Zhang, Y. Functional genetic variants and mental disorders: Single nucleotide polymorphisms and their effects in genes involved in mental disorders. 2009.